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MessagePosté le: Jeu 12 Mai 2016 - 23:54    Sujet du message: HDTV/PRECU-RSORS-POSTMORTE-M Répondre en citant

== bit.ly/1ZKwWcT

== bit.ly/1ZKwWcT

== bit.ly/1ZKwWcT

== bit.ly/1ZKwWcT

== bit.ly/1ZKwWcT


precursors,,,,postmortem,,,,shared,,,,files:,,,,Here,,,,you,,,,can,,,,find,,,,precursors,,,,postmortem,,,,shared,,,,files,,,,we,,,,have,,,,found,,,,in,,,,our,,,,database3,,crackedjungle,,brothers,,straightthe,,sickness,,Weckt,,die,,TotenDavid,,Bowie,,,Tonightphill,,pratt,,star,,wars,,dubsniper3d,,hackAlison,,Moyet,,,Alfhead,,automaticaWave,,Gotik,,Treffenleroy,,smart,,propagandaweird,,owl,,nuclear,,technologyimaginations,,of,,lightYour,,Chaos,,Days,,Are,,Numberedrevolutionaries,,dub,,out,,her,,blouse,,&,,skirthellnationBlack,,Flag,,,My,,War,,Home,,Youtube,,to,,mp3,,Contact/DMCA,,2016,,,,All,,rights,,reserved,,,,TraDownload.com,,-,,Shared,,files,,and,,Streams,,We,,,,further,,,,limited,,,,tissue,,,,samples,,,,,particularly,,,,in,,,,choosing,,,,controls,,,,,to,,,,those,,,,without,,,,concurrent,,,,severe,,,,cerebrovascular,,,,pathology,,,,and,,,,reported,,,,dementia,,,,that,,,,could,,,,confound,,,,urate,,,,measurements3[PubMed]12We,,,measured,,,urate,,,and,,,other,,,purine,,,pathway,,,analytes,,,in,,,frontal,,,and,,,temporal,,,cortex,,,,striatum,,,,and,,,cerebellum,,,,using,,,HPLC,,,with,,,electrochemical,,,and,,,ultraviolet,,,detection.ResultsAge,,,was,,,well-matched,,,among,,,groupsXanthine,,,and,,,hypoxanthine,,,were,,,more,,,concentrated,,,in,,,striatal,,,tissue,,,than,,,in,,,other,,,brain,,,regions.ConclusionsThough,,,limited,,,in,,,sample,,,size,,,,these,,,findings,,,lend,,,support,,,to,,,the,,,inverse,,,association,,,between,,,urate,,,levels,,,and,,,PD,,,,as,,,well,,,as,,,possibly,,,ADhome,,files,,streams,,YouTube,,to,,mp3,,support,,IntroductionIncreasing,,,,clinical,,,,,epidemiological,,,,,and,,,,laboratory,,,,evidence,,,,suggests,,,,that,,,,urate,,,,(or,,,,uric,,,,acid),,,,may,,,,play,,,,a,,,,role,,,,in,,,,neurodegenerative,,,,disease,,,,,and,,,,Parkinson,,,,disease,,,,(PD),,,,in,,,,particular2011;63:31363141Neurodegener,,,,DisGelb,,,DJ,,,,Oliver,,,E,,,,Gilman,,,S5–10,,samples,,for,,each,,disease,,state,,,gender,,,and,,specified,,brain,,region,,were,,examined.Table,,1Group,,StatisticsUrate,,and,,precursor,,measurementsWe,,compared,,urate,,pathway,,metabolites,,in,,human,,postmortem,,tissue,,across,,select,,brain,,regions,,and,,neurodegenerative,,diseases,,,including,,PD,,,DLB,,,AD,,,and,,controlsMcKeith,,IG,,,Dickson,,DW,,,Lowe,,J,,,Emre,,M,,,O'Brien,,JT,,,Feldman,,H,,,Cummings,,J,,,Duda,,JE,,,Lippa,,C,,,Perry,,EK,,,Aarsland,,D,,,Arai,,H,,,Ballard,,CG,,,Boeve,,B,,,Burn,,DJ,,,Costa,,D,,,Del,,Ser,,T,,,Dubois,,B,,,Galasko,,D,,,Gauthier,,S,,,Goetz,,CG,,,Gomez-Tortosa,,E,,,Halliday,,G,,,Hansen,,LA,,,Hardy,,J,,,Iwatsubo,,T,,,Kalaria,,RN,,,Kaufer,,D,,,Kenny,,RA,,,Korczyn,,A,,,Kosaka,,K,,,Lee,,VM,,,Lees,,A,,,Litvan,,I,,,Londos,,E,,,Lopez,,OL,,,Minoshima,,S,,,Mizuno,,Y,,,Molina,,JA,,,Mukaetova-Ladinska,,EB,,,Pasquier,,F,,,Perry,,RH,,,Schulz,,JB,,,Trojanowski,,JQ,,,Yamada,,MView,,,,full,,,,text,,,,Neurochemistry,,,,InternationalVolume,,,,29,,,,,Issue,,,,3,,,,,September,,,,1996,,,,,Pages,,,,239245,,,,About,,,,ScienceDirect,,,,Contact,,,,and,,,,support,,,,Terms,,,,and,,,,conditions,,,,Privacy,,,,policy,,,,Copyright,,,,,,,,2016,,,,Elsevier,,,,B.VTissue,,samples,,were,,primarily,,obtained,,from,,one,,source,,,the,,MGH-ADRC,,,and,,thus,,limited,,in,,scope,,and,,regions,,availableBox,,100159,,,Gainesville,,,FL,,32610Author,,information,,,,Copyright,,and,,License,,information,,Copyright,,notice,,and,,DisclaimerThe,,publisher's,,final,,edited,,version,,of,,this,,article,,is,,available,,at,,Neurodegener,,DisSee,,other,,articles,,in,,PMC,,that,,cite,,the,,published,,article[PubMed]9Switch,,,to,,,Mobile,,,Site,,,Recommended,,,articles,,,No,,,articles,,,found2000;15:4049Hyman,,,BT,,,,Trojanowski,,,JQSimilar,,functions,,of,,uric,,acid,,and,,ascorbate,,in,,man?,,NatureMeasurements,,,for,,,each,,,sample,,,were,,,normalized,,,to,,,the,,,methyldopa,,,standard,,,peak,,,and,,,wet,,,weight,,,of,,,tissue,,,analyzed,,,(expressed,,,as,,,ng,,,of,,,analyte,,,per,,,wet,,,weight,,,of,,,brain,,,tissue,,,(wwt),,,in,,,figures).Statistical,,,analysisAll,,,statistical,,,analyses,,,were,,,performed,,,in,,,SPSS,,,20.0,,,(IBM,,,Corp.)Inosine,,,levels,,,displayed,,,a,,,disease,,,effect,,,(F[4,162],,,=,,,2.71,,,,p=0.047),,,with,,,relative,,,increase,,,in,,,AD,,,vsBiochim,,,,Biophys,,,,ActaThus,,,the,,higher,,urate,,levels,,we,,observed,,in,,postmortem,,DLB,,brain,,could,,reflect,,associated,,vascular,,risk,,factors,,,which,,have,,been,,shown,,to,,be,,a,,determinant,,of,,DLB,,diagnosis.[34],,Vascular,,confounds,,,however,,,would,,not,,readily,,explain,,why,,urate,,was,,elevated,,in,,DLB,,but,,not,,in,,AD,,,which,,is,,similarly,,thought,,to,,be,,more,,likely,,among,,those,,with,,vascular,,risk,,factorsAlthough,,cardiovascular,,risk,,is,,associated,,with,,elevated,,urate,,levels,[40],,it,,remains,,unclear,,whether,,this,,translates,,to,,higher,,levels,,in,,brain.In,,conclusion,,,this,,study,,provides,,further,,support,,for,,a,,role,,of,,urate,,in,,PD,,by,,strengthening,,the,,direct,,evidence,,that,,urate,,levels,,in,,degenerating,,brain,,tissue,,of,,male,,PD,,patients,,,as,,well,,as,,in,,their,,CSF,,and,,blood,,,are,,lower,,than,,in,,control,,subjects[PubMed]34[PubMed]8Grootveld,,,M,,,,Halliwell,,,B 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